Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

Obesity and its metabolic consequences are a major public health concern worldwide. Obesity is associated with overactivity of the endocannabinoid system, which is involved in the regulation of appetite, lipogenesis, and insulin resistance. Cannabinoid-1 receptor (CB(1)R) antagonists reduce body wei...

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Detalhes bibliográficos
Main Authors: Tam, Joseph, Vemuri, V. Kiran, Liu, Jie, Bátkai, Sándor, Mukhopadhyay, Bani, Godlewski, Grzegorz, Osei-Hyiaman, Douglas, Ohnuma, Shinobu, Ambudkar, Suresh V., Pickel, James, Makriyannis, Alexandros, Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912197/
https://ncbi.nlm.nih.gov/pubmed/20664173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42551
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