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CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral cavernous malformations 1 protein (CCM1), CCM2, and CCM3. CCM1, CCM2, and CCM3 interact biochemically in a pathway require...

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Detalhes bibliográficos
Main Authors: Zheng, Xiangjian, Xu, Chong, Di Lorenzo, Annarita, Kleaveland, Benjamin, Zou, Zhiying, Seiler, Christoph, Chen, Mei, Cheng, Lan, Xiao, Jiping, He, Jie, Pack, Michael A., Sessa, William C., Kahn, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912181/
https://ncbi.nlm.nih.gov/pubmed/20592472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39679
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