Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α display unique and sometimes opposing activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis. Macrophages exposed to hypoxia accumulate both HIF-1α and HIF-2α, and overexpression of HIF-2α in tumor-associated macroph...

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Main Authors: Imtiyaz, Hongxia Z., Williams, Emily P., Hickey, Michele M., Patel, Shetal A., Durham, Amy C., Yuan, Li-Jun, Hammond, Rachel, Gimotty, Phyllis A., Keith, Brian, Simon, M. Celeste
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912179/
https://ncbi.nlm.nih.gov/pubmed/20644254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39506
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