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Inhibition of Human T-Cell Proliferation by Mammalian Target of Rapamycin (mTOR) Antagonists Requires Noncoding RNA Growth-Arrest-Specific Transcript 5 (GAS5)

The central importance of the serine/threonine protein kinase mTOR (mammalian Target of Rapamycin) in the control of cell growth and proliferation is well established. However, our knowledge both of the upstream pathways controlling mTOR activity and of the downstream events mediating these effects...

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Bibliografiske detaljer
Main Authors: Mourtada-Maarabouni, Mirna, Hasan, Anwar M., Farzaneh, Farzin, Williams, Gwyn T.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912054/
https://ncbi.nlm.nih.gov/pubmed/20421347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064055
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