Human Recombinant Vascular Endothelial Growth Factor Reduces Necrosis and Enhances Hepatocyte Regeneration in a Mouse Model of Acetaminophen Toxicity

We reported previously that vascular endothelial growth factor (VEGF) was increased in acetaminophen (APAP) toxicity in mice and treatment with a VEGF receptor inhibitor reduced hepatocyte regeneration. The effect of human recombinant VEGF (hrVEGF) on APAP toxicity in the mouse was examined. In earl...

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Autori principali: Donahower, Brian C., McCullough, Sandra S., Hennings, Leah, Simpson, Pippa M., Stowe, Cindy D., Saad, Ali G., Kurten, Richard C., Hinson, Jack A., James, Laura P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
Soggetti:
Toxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912052/
https://ncbi.nlm.nih.gov/pubmed/20363854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.163840
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