Lubiprostone Reverses the Inhibitory Action of Morphine on Intestinal Secretion in Guinea Pig and Mouse

Lubiprostone activates ClC-2 chloride channels in epithelia. It is approved for treatment of chronic idiopathic constipation in adults and constipation-predominate irritable bowel syndrome in women. We tested a hypothesis that lubiprostone can reverse the constipating action of morphine and investig...

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Autori principali: Fei, Guijun, Raehal, Kirsten, Liu, Sumei, Qu, Mei-Hua, Sun, Xiaohong, Wang, Guo-Du, Wang, Xi-Yu, Xia, Yun, Schmid, Cullen L., Bohn, Laura M., Wood, Jackie D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
Soggetti:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912047/
https://ncbi.nlm.nih.gov/pubmed/20406855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.166116
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