Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes

INTRODUCTION: The importance of mechanical signals in normal and inflamed cartilage is well established. Chondrocytes respond to changes in the levels of proinflammatory cytokines and mechanical signals during inflammation. Cytokines like interleukin (IL)-1β suppress homeostatic mechanisms and inhib...

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Hlavní autoři: Perera, Priyangi M, Wypasek, Ewa, Madhavan, Shashi, Rath-Deschner, Birgit, Liu, Jie, Nam, Jin, Rath, Bjoern, Huang, Yan, Deschner, James, Piesco, Nicholas, Wu, Chuanyue, Agarwal, Sudha
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911896/
https://ncbi.nlm.nih.gov/pubmed/20509944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3039
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