Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes

INTRODUCTION: The importance of mechanical signals in normal and inflamed cartilage is well established. Chondrocytes respond to changes in the levels of proinflammatory cytokines and mechanical signals during inflammation. Cytokines like interleukin (IL)-1β suppress homeostatic mechanisms and inhib...

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Main Authors: Perera, Priyangi M, Wypasek, Ewa, Madhavan, Shashi, Rath-Deschner, Birgit, Liu, Jie, Nam, Jin, Rath, Bjoern, Huang, Yan, Deschner, James, Piesco, Nicholas, Wu, Chuanyue, Agarwal, Sudha
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911896/
https://ncbi.nlm.nih.gov/pubmed/20509944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3039
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