The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by hydrogen peroxide to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid) respectively. Specificity constants indicate that SCN(−) is a major substrate for MPO. HOSCN is also a major o...

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Detalhes bibliográficos
Main Authors: Lane, Amanda E., Tan, Joanne T. M., Hawkins, Clare L., Heather, Alison K., Davies, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911680/
https://ncbi.nlm.nih.gov/pubmed/20528774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100082
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