Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties

Structure-activity relationship studies were carried out on macrocyclic hexaoxazole (6OTD) dimers, whose core structure stabilizes telomeric G-quadruplexes (G4). Two new 6OTD dimers having side chain amine and guanidine functional groups were synthesized and evaluated for their stabilizing ability a...

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Detalhes bibliográficos
Main Authors: Iida, Keisuke, Tera, Masayuki, Hirokawa, Takatsugu, Shin-ya, Kazuo, Nagasawa, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911606/
https://ncbi.nlm.nih.gov/pubmed/20700415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/217627
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