Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

AIMS: Human carboxylesterase 1 (CES1) hydrolyzes irinotecan to produce an active metabolite SN-38 in the liver. The human CES1 gene family consists of two functional genes, CES1A1 (1A1) and CES1A2 (1A2), which are located tail-to-tail on chromosome 16q13-q22.1 (CES1A2-1A1). The pseudogene CES1A3 (1A...

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Autori principali: Sai, Kimie, Saito, Yoshiro, Tatewaki, Naoko, Hosokawa, Masakiyo, Kaniwa, Nahoko, Nishimaki-Mogami, Tomoko, Naito, Mikihiko, Sawada, Jun-ichi, Shirao, Kuniaki, Hamaguchi, Tetsuya, Yamamoto, Noboru, Kunitoh, Hideo, Tamura, Tomohide, Yamada, Yasuhide, Ohe, Yuichiro, Yoshida, Teruhiko, Minami, Hironobu, Ohtsu, Atsushi, Matsumura, Yasuhiro, Saijo, Nagahiro, Okuda, Haruhiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
Soggetti:
Pharmacogenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911552/
https://ncbi.nlm.nih.gov/pubmed/20653675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03695.x
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