Insertion of Epicatechin Gallate into the Cytoplasmic Membrane of Methicillin-resistant Staphylococcus aureus Disrupts Penicillin-binding Protein (PBP) 2a-mediated β-Lactam Resistance by Delocalizing PBP2

Epicatechin gallate (ECg) sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin and other β-lactam agents; it also reduces the secretion of virulence-associated proteins, prevents biofilm formation, and induces gross morphological changes in MRSA cells without compromising the g...

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Bibliographic Details
Main Authors: Bernal, Patricia, Lemaire, Sandrine, Pinho, Mariana G., Mobashery, Shahriar, Hinds, Jason, Taylor, Peter W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911331/
https://ncbi.nlm.nih.gov/pubmed/20516078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114793
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