Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation

In platelets, STIM1 has been recognized as the key regulatory protein in store-operated Ca(2+) entry (SOCE) with Orai1 as principal Ca(2+) entry channel. Both proteins contribute to collagen-dependent arterial thrombosis in mice in vivo. It is unclear whether STIM2 is involved. A key platelet respon...

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Dettagli Bibliografici
Autori principali: Gilio, Karen, van Kruchten, Roger, Braun, Attila, Berna-Erro, Alejandro, Feijge, Marion A. H., Stegner, David, van der Meijden, Paola E. J., Kuijpers, Marijke J. E., Varga-Szabo, David, Heemskerk, Johan W. M., Nieswandt, Bernhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911319/
https://ncbi.nlm.nih.gov/pubmed/20519511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108696
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