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The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme

Cbl proteins are ubiquitin ligases (E3s) that play a significant role in regulating tyrosine kinase signaling. There are three mammalian family members: Cbl, Cbl-b, and Cbl-c. All have a highly conserved N-terminal tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal prol...

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Hlavní autoři: Ryan, Philip E., Sivadasan-Nair, Nina, Nau, Marion M., Nicholas, Sarah, Lipkowitz, Stanley
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911298/
https://ncbi.nlm.nih.gov/pubmed/20525694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091157
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