Reactive Oxygen Species, Ki-Ras, and Mitochondrial Superoxide Dismutase Cooperate in Nerve Growth Factor-induced Differentiation of PC12 Cells

Nerve growth factor (NGF) induces terminal differentiation in PC12, a pheochromocytoma-derived cell line. NGF binds a specific receptor on the membrane and triggers the ERK1/2 cascade, which stimulates the transcription of neural genes. We report that NGF significantly affects mitochondrial metaboli...

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Bibliographische Detailangaben
Hauptverfasser: Cassano, Silvana, Agnese, Savina, D'Amato, Valentina, Papale, Massimo, Garbi, Corrado, Castagnola, Patrizio, Ruocco, Maria Rosaria, Castellano, Immacolata, De Vendittis, Emmanuele, Santillo, Mariarosaria, Amente, Stefano, Porcellini, Antonio, Avvedimento, Enrico Vittorio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911279/
https://ncbi.nlm.nih.gov/pubmed/20495008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098525
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