Diclofenac-Induced Apoptosis in the Neuroblastoma Cell Line SH-SY5Y: Possible Involvement of the Mitochondrial Superoxide Dismutase

Diclofenac, a nonsteroidal anti-inflammatory drug, induces apoptosis on the neuroblastoma cell line SH-SY5Y through a mitochondrial dysfunction, affecting some antioxidant mechanisms. Indeed, the time- and dose-dependent increase of apoptosis is associated to an early enhancement of the reactive oxy...

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Detalhes bibliográficos
Main Authors: Cecere, Francesca, Iuliano, Annarita, Albano, Francesco, Zappelli, Claudia, Castellano, Immacolata, Grimaldi, Pasquale, Masullo, Mariorosario, De Vendittis, Emmanuele, Ruocco, Maria Rosaria
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896885/
https://ncbi.nlm.nih.gov/pubmed/20625417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/801726
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