A Fusion of GMCSF and IL-21 Initiates Hypersignaling Through the IL-21Rα Chain With Immune Activating and Tumoricidal Effects In Vivo

We hypothesized that fusing granulocyte-macrophage colony-stimulation factor (GMCSF) and interleukin (IL)-21 as a single bifunctional cytokine (hereafter GIFT-21) would lead to synergistic anticancer immune effects because of their respective roles in mediating inflammation. Mechanistic analysis of...

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Detalhes bibliográficos
Main Authors: Williams, Patrick, Rafei, Moutih, Bouchentouf, Manaf, Raven, Jennifer, Yuan, Shala, Cuerquis, Jessica, Forner, Kathy A, Birman, Elena, Galipeau, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911248/
https://ncbi.nlm.nih.gov/pubmed/20389285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.49
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