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Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
B lymphocyte hyperactivation and hypergammaglobulinemia are pathogenic manifestations of HIV-1 infection. Here we provide evidence that these B cell defects are driven by factors produced by HIV-1 infected macrophages and that Nef is necessary for this activity. In vitro, HIV-1 infected macrophages...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911124/ https://ncbi.nlm.nih.gov/pubmed/18621011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.05.015 |
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