The Structure-Activity Relationships of A-Ring-Substituted Aromathecin Topoisomerase I Inhibitors Strongly Support a Camptothecin-Like Binding Mode

Aromathecins are inhibitors of human topoisomerase I (Top1). These compounds are composites of several heteroaromatic systems, namely the camptothecins and indenoisoquinolines, and they possess notable Top1 inhibition and cytotoxicity when substituted at position 14. The SAR of these compounds overl...

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Auteurs principaux: Cinelli, Maris A., Morrell, Andrew E., Dexheimer, Thomas S., Agama, Keli, Agrawal, Surbhi, Pommier, Yves, Cushman, Mark
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911012/
https://ncbi.nlm.nih.gov/pubmed/20630766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.040
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