Isofagomine Induced Stabilization of Glucocerebrosidase

Structurally destabilizing mutations in acid β-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical evaluation for the treatment of GD. An X-ray crystallo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kornhaber, Gregory J., Tropak, Michael B., Maegawa, Gustavo H., Tuske, Steven J., Coales, Stephen J., Mahuran, Don J., Hamuro, Yoshitomo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910746/
https://ncbi.nlm.nih.gov/pubmed/18932186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800249
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares