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Isofagomine Induced Stabilization of Glucocerebrosidase

Structurally destabilizing mutations in acid β-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical evaluation for the treatment of GD. An X-ray crystallo...

詳細記述

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書誌詳細
主要な著者: Kornhaber, Gregory J., Tropak, Michael B., Maegawa, Gustavo H., Tuske, Steven J., Coales, Stephen J., Mahuran, Don J., Hamuro, Yoshitomo
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910746/
https://ncbi.nlm.nih.gov/pubmed/18932186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800249
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