Isofagomine Induced Stabilization of Glucocerebrosidase

Structurally destabilizing mutations in acid β-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical evaluation for the treatment of GD. An X-ray crystallo...

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Huvudupphovsmän: Kornhaber, Gregory J., Tropak, Michael B., Maegawa, Gustavo H., Tuske, Steven J., Coales, Stephen J., Mahuran, Don J., Hamuro, Yoshitomo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910746/
https://ncbi.nlm.nih.gov/pubmed/18932186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800249
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