Isofagomine Induced Stabilization of Glucocerebrosidase

Structurally destabilizing mutations in acid β-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical evaluation for the treatment of GD. An X-ray crystallo...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Kornhaber, Gregory J., Tropak, Michael B., Maegawa, Gustavo H., Tuske, Steven J., Coales, Stephen J., Mahuran, Don J., Hamuro, Yoshitomo
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910746/
https://ncbi.nlm.nih.gov/pubmed/18932186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800249
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares