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Isofagomine Induced Stabilization of Glucocerebrosidase
Structurally destabilizing mutations in acid β-glucosidase (GCase) can result in Gaucher disease (GD). The iminosugar isofagomine (IFG), a competitive inhibitor and a potential pharmacological chaperone of GCase, is currently undergoing clinical evaluation for the treatment of GD. An X-ray crystallo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910746/ https://ncbi.nlm.nih.gov/pubmed/18932186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800249 |
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