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Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90

BACKGROUND: Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. Enhanced levels of HIF-1α, the oxygen-regulated subunit of HIF-1, is often associated with increased tumour angiogenesis, metastasis, therapeutic resistance and p...

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Bibliographic Details
Main Authors: Trisciuoglio, Daniela, Gabellini, Chiara, Desideri, Marianna, Ziparo, Elio, Zupi, Gabriella, Del Bufalo, Donatella
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910721/
https://ncbi.nlm.nih.gov/pubmed/20668552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011772
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