Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant

dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn...

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Bibliographic Details
Main Authors: Jin, Bo, Sun, Tao, Yu, Xiao-Hong, Liu, Chao-Qun, Yang, Ying-Xiang, Lu, Ping, Fu, Shan-Feng, Qiu, Hui-Bin, Yeo, Anthony E. T.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910503/
https://ncbi.nlm.nih.gov/pubmed/20671921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/690438
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