Adipose acyl-CoA synthetase-1 (ACSL1) directs fatty acids towards β-oxidation and is required for cold thermogenesis

Acyl-CoA synthetase-1 (ACSL) contributes 80% of total ACSL activity in adipose tissue and was believed to be essential for the synthesis of triacylglycerol. We predicted that an adipose-specific knockout of ACSL1 (Acsl1(A−/−)) would be lipodystrophic, but, compared to controls, Acsl1(A−/−) mice had...

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Autori principali: Ellis, Jessica M., Li, Lei O., Wu, Pei-Chi, Koves, Timothy R., Ilkayeva, Olga, Stevens, Robert D., Watkins, Steven M., Muoio, Deborah M., Coleman, Rosalind A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910420/
https://ncbi.nlm.nih.gov/pubmed/20620995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.05.012
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