Purkinje Cell Calcium Dysregulation Is the Cellular Mechanism that Underlies Catecholaminergic Polymorphic Ventricular Tachycardia

BACKGROUND: Inherited arrhythmias can be caused by mutations in the cardiac ryanodine receptor (RyR2). The cellular source of these arrhythmias is unknown. Isolated RyR2(R4496C) mouse ventricular myocytes display arrhythmogenic activity related to spontaneous Ca(2+) release during diastole. On the o...

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Hauptverfasser: Herron, Todd J., Milstein, Michelle L., Anumonwo, Justus, Priori, Silvia G., Jalife, José
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910215/
https://ncbi.nlm.nih.gov/pubmed/20538074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.06.010
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