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Purkinje Cell Calcium Dysregulation Is the Cellular Mechanism that Underlies Catecholaminergic Polymorphic Ventricular Tachycardia
BACKGROUND: Inherited arrhythmias can be caused by mutations in the cardiac ryanodine receptor (RyR2). The cellular source of these arrhythmias is unknown. Isolated RyR2(R4496C) mouse ventricular myocytes display arrhythmogenic activity related to spontaneous Ca(2+) release during diastole. On the o...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910215/ https://ncbi.nlm.nih.gov/pubmed/20538074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.06.010 |
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