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mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice

We investigated the effect of the mitochondrial DNA (mtDNA) polymorphism G10398A found in African-American women with aggressive breast cancer on apoptosis and tumorigenesis. We generated human cytoplasmic hybrid (cybrid) by repopulation of recipient ρ(0) cells (devoid of mtDNA) with donor mtDNA der...

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Auteurs principaux: Kulawiec, Mariola, Owens, Kjerstin M, Singh, Keshav K
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909846/
https://ncbi.nlm.nih.gov/pubmed/19763141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jhg.2009.89
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