Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

The liver and pancreas share a common origin and coexpress several transcription factors. To gain insight into the transcriptional networks regulating the function of these tissues, we globally identify binding sites for FOXA2 in adult mouse islets and liver, PDX1 in islets, and HNF4A in liver. Beca...

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Autors principals: Hoffman, Brad G., Robertson, Gordon, Zavaglia, Bogard, Beach, Mike, Cullum, Rebecca, Lee, Sam, Soukhatcheva, Galina, Li, Leping, Wederell, Elizabeth D., Thiessen, Nina, Bilenky, Mikhail, Cezard, Timothee, Tam, Angela, Kamoh, Baljit, Birol, Inanc, Dai, Derek, Zhao, YongJun, Hirst, Martin, Verchere, C. Bruce, Helgason, Cheryl D., Marra, Marco A., Jones, Steven J.M., Hoodless, Pamela A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909568/
https://ncbi.nlm.nih.gov/pubmed/20551221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.104356.109
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