Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas

AIM: To investigate aberrant DNA methylation of CpG islands and subsequent low- or high-level DNA microsatellite instability (MSI) which is assumed to drive colon carcinogenesis. METHODS: DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patien...

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Hlavní autoři: Psofaki, Vasiliki, Kalogera, Chryssoula, Tzambouras, Nikolaos, Stephanou, Dimitrios, Tsianos, Epameinondas, Seferiadis, Konstantin, Kolios, Georgios
Médium: Artigo
Jazyk:Inglês
Vydáno: The WJG Press and Baishideng 2010
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Brief Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909555/
https://ncbi.nlm.nih.gov/pubmed/20653064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v16.i28.3553
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