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Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing
Tumor-driving mutations in the TP53 gene occur frequently in human cancers. These inactivating mutations arise predominantly from a single-point mutation in the DNA-binding domain of this tumor suppressor gene (i.e., exons 4–9). The human p53 knock-in (Hupki) mouse model was constructed using gene-t...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Federation of American Societies for Experimental Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909297/ https://ncbi.nlm.nih.gov/pubmed/20371617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-157263 |
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