Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts

Acrylamide is a suspected human carcinogen formed during high-temperature cooking of starch-rich foods. It is metabolised by cytochrome P450 2E1 to its reactive metabolite glycidamide, which forms pre-mutagenic DNA adducts. Using the human TP53 knock-in (Hupki) mouse embryo fibroblasts (HUFs) immort...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Hölzl-Armstrong, Lisa, Kucab, Jill E., Moody, Sarah, Zwart, Edwin P., Loutkotová, Lucie, Duffy, Veronica, Luijten, Mirjam, Gamboa da Costa, Gonçalo, Stratton, Michael R., Phillips, David H., Arlt, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Genotoxicity and Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655573/
https://ncbi.nlm.nih.gov/pubmed/32886187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02878-0
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