Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts: p53/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE

Research on cell senescence and immortalization of murine embryonic fibroblasts (MEFs) has revealed important clues about genetic control of senescence in humans. To investigate senescence and genetic alterations in the p53 pathway that lead to senescence bypass in culture, we compared the behavior...

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Detalhes bibliográficos
Main Authors: Whibley, Catherine, Odell, Adam F., Nedelko, Tatiana, Balaburski, Gregor, Murphy, Maureen, Liu, Zhipei, Stevens, Louisa, Walker, John H., Routledge, Michael, Hollstein, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857011/
https://ncbi.nlm.nih.gov/pubmed/20118236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064444
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