Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts: p53/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE

Research on cell senescence and immortalization of murine embryonic fibroblasts (MEFs) has revealed important clues about genetic control of senescence in humans. To investigate senescence and genetic alterations in the p53 pathway that lead to senescence bypass in culture, we compared the behavior...

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Hlavní autoři: Whibley, Catherine, Odell, Adam F., Nedelko, Tatiana, Balaburski, Gregor, Murphy, Maureen, Liu, Zhipei, Stevens, Louisa, Walker, John H., Routledge, Michael, Hollstein, Monica
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857011/
https://ncbi.nlm.nih.gov/pubmed/20118236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064444
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