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FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy

Muscle atrophy is a consequence of chronic diseases (e.g., diabetes) and glucocorticoid-induced insulin resistance that results from enhanced activity of the ubiquitin-proteasome pathway. The PI3K/Akt pathway inhibits the FOXO-mediated transcription of the muscle-specific E3 ligase atrogin-1/MAFbx (...

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Bibliografiske detaljer
Main Authors: Zheng, Bin, Ohkawa, Sakae, Li, Haiyan, Roberts-Wilson, Tiffany K., Price, S. Russ
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909288/
https://ncbi.nlm.nih.gov/pubmed/20371624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-151480
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