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Monotonicity, frustration, and ordered response: an analysis of the energy landscape of perturbed large-scale biological networks

BACKGROUND: For large-scale biological networks represented as signed graphs, the index of frustration measures how far a network is from a monotone system, i.e., how incoherently the system responds to perturbations. RESULTS: In this paper we find that the frustration is systematically lower in tra...

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Bibliografiske detaljer
Main Authors: Iacono, Giovanni, Altafini, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909160/
https://ncbi.nlm.nih.gov/pubmed/20537143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-83
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