Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin

OBJECTIVES: Although statins are efficacious for lowering LDL-cholesterol (LDLC), there is wide inter-individual variation in response. We tested the extent to which combined effects of common alleles of LDLR and HMGCR can contribute to this variability. METHODS AND RESULTS: Haplotypes in the LDLR 3...

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Autores principales: Mangravite, Lara M., Medina, Marisa Wong, Cui, Jinrui, Pressman, Sheila, Smith, Joshua D., Rieder, Mark J., Guo, Xiuqing, Nickerson, Deborah A., Rotter, Jerome I., Krauss, Ronald M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909117/
https://ncbi.nlm.nih.gov/pubmed/20413733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.203273
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