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HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting enzyme in the cholesterol biosynthesis pathway and is inhibited by statins, a class of cholesterol-lowering drugs. Expression of an alternatively spliced HMGCR transcript lacking exon 13, HMGCR13(−), has been implicate...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3869353/ https://ncbi.nlm.nih.gov/pubmed/24001602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt422 |
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