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Significant Increase in Phenacetin Oxidation on L382V Substitution in Human Cytochrome P450 1A2
Human CYP1A2 is an important drug-metabolizing enzyme, similar in sequence to CYP1A1 but with distinct substrate specificity. We have previously shown that residue 382 affected CYP1A1 and CYP1A2 specificities with alkoxyresorufins. To determine whether this residue is also important for the metaboli...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908983/ https://ncbi.nlm.nih.gov/pubmed/20335269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.030767 |
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