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Emergent bistability by a growth-modulating positive feedback circuit
A synthetic gene circuit is often engineered by considering the host cell as an invariable “chassis”. Circuit activation, however, may modulate host physiology, which in turn can drastically impact circuit behavior. We illustrate this point by a simple circuit consisting of mutant T7 RNA polymerase...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908482/ https://ncbi.nlm.nih.gov/pubmed/19801994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.218 |
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