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Neurotoxic effects of TDP-43 overexpression in C. elegans
RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient i...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908471/ https://ncbi.nlm.nih.gov/pubmed/20530643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq230 |
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