The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ) intermediates that are ultimately resolved by nucleolytic enzymes. An N-terminal fragment of human GEN1 has recently been shown to act as a Holliday junction resolvase, but litt...

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Autors principals: Bailly, Aymeric P., Freeman, Alasdair, Hall, Julie, Déclais, Anne-Cécile, Alpi, Arno, Lilley, David M. J., Ahmed, Shawn, Gartner, Anton
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908289/
https://ncbi.nlm.nih.gov/pubmed/20661466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001025
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