PRAS40 ACTS AS A NODAL REGULATOR OF HIGH GLUCOSE-INDUCED TORC1 ACTIVATION IN GLOMERULAR MESANGIAL CELL HYPERTROPHY

Diabetic nephropathy manifests aberrant activation of TORC1, which senses key signals to modulate protein synthesis and renal hypertrophy. PRAS40 has recently been identified as a raptor-interacting protein and is a component and a constitutive inhibitor of TORC1. The mechanism by which high glucose...

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Main Authors: Dey, Nirmalya, Ghosh-Choudhury, Nandini, Das, Falguni, Li, Xiaonan, Venkatesan, Balachandar, Barnes, Jeffrey L., Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908198/
https://ncbi.nlm.nih.gov/pubmed/20629086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22186
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