Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

BACKGROUND: Extensive genetic diversity in vaccine antigens may contribute to the lack of efficacy of blood stage malaria vaccines. Apical membrane antigen-1 (AMA1) is a leading blood stage malaria vaccine candidate with extreme diversity, potentially limiting its efficacy against infection and dise...

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Detalhes bibliográficos
Main Authors: Ouattara, Amed, Mu, Jianbing, Takala-Harrison, Shannon, Saye, Renion, Sagara, Issaka, Dicko, Alassane, Niangaly, Amadou, Duan, Junhui, Ellis, Ruth D, Miller, Louis H, Su, Xin-zhuan, Plowe, Christopher V, Doumbo, Ogobara K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908102/
https://ncbi.nlm.nih.gov/pubmed/20565971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-9-175
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