Platelets mediate cytotoxic T lymphocyte–induced liver damage

We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severi...

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Main Authors: Iannacone, Matteo, Sitia, Giovanni, Isogawa, Masanori, Marchese, Patrizia, Castro, Maria G, Lowenstein, Pedro R, Chisari, Francis V, Ruggeri, Zaverio M, Guidotti, Luca G
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908083/
https://ncbi.nlm.nih.gov/pubmed/16258538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1317
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