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Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin β3. Lethal hemorrhagic anemia is mediated by virus-induced IFN-α/β that...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206587/ https://ncbi.nlm.nih.gov/pubmed/18184798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711200105 |
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