Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus

We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin β3. Lethal hemorrhagic anemia is mediated by virus-induced IFN-α/β that...

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Bibliographic Details
Main Authors: Iannacone, Matteo, Sitia, Giovanni, Isogawa, Masanori, Whitmire, Jason K., Marchese, Patrizia, Chisari, Francis V., Ruggeri, Zaverio M., Guidotti, Luca G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206587/
https://ncbi.nlm.nih.gov/pubmed/18184798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711200105
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