DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1

[Image: see text] The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than mitomycin C (MC). We recently documented that an increased proportion of mitosene1-β-adduct formation occurs in human cells treated with DMC in comparison to t...

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Autors principals: Boamah, Ernest K., Brekman, Angelika, Tomasz, Maria, Myeku, Natura, Figueiredo-Pereira, Maria, Hunter, Senyene, Meyer, Joel, Bhosle, Rahul C., Bargonetti, Jill
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907727/
https://ncbi.nlm.nih.gov/pubmed/20536192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900420k
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