Proprotein Convertase Inhibition Results in Decreased Skin Cell Proliferation, Tumorigenesis, and Metastasis

PACE4 is a proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor progression. PACE4 overexpression significantly increased the susceptibility to carcinogenesis, leading to enhanced tumor cell proliferation and premature degradation of the baseme...

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Bibliographic Details
Main Authors: Bassi, Daniel E, Zhang, Jirong, Cenna, Jonathan, Litwin, Samuel, Cukierman, Edna, Klein-Szanto, Andres JP
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907578/
https://ncbi.nlm.nih.gov/pubmed/20651981
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