Neutralizing TIMP1 Restores Fecundity in a Rat Model of Endometriosis and Treating Control Rats with TIMP1 Causes Anomalies in Ovarian Function and Embryo Development

Human and rat endometriotic lesions synthesize and secrete tissue inhibitor of metalloproteinase 1 (TIMP1). More TIMP1 localizes in the ovarian theca in an established rat model for endometriosis (Endo) when compared to surgical controls (Sham). We hypothesized that endometriotic TIMP1 secreted into...

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Detalhes bibliográficos
Main Authors: Stilley, Julie A.W., Birt, Julie A., Nagel, Susan C., Sutovsky, Miriam, Sutovsky, Peter, Sharpe-Timms, Kathy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907283/
https://ncbi.nlm.nih.gov/pubmed/20410455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.083287
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