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Independent filtering increases detection power for high-throughput experiments

With high-dimensional data, variable-by-variable statistical testing is often used to select variables whose behavior differs across conditions. Such an approach requires adjustment for multiple testing, which can result in low statistical power. A two-stage approach that first filters variables by...

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Autori principali: Bourgon, Richard, Gentleman, Robert, Huber, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906865/
https://ncbi.nlm.nih.gov/pubmed/20460310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914005107
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