Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion

In healthy monocytes, Toll-like receptor (TLR) engagement induces production of reactive oxygen species (ROS), followed by an antioxidant response involved in IL-1β processing and secretion. Markers of the antioxidant response include intracellular thioredoxin and extracellular release of reduced cy...

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Bibliographic Details
Main Authors: Tassi, Sara, Carta, Sonia, Delfino, Laura, Caorsi, Roberta, Martini, Alberto, Gattorno, Marco, Rubartelli, Anna
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906851/
https://ncbi.nlm.nih.gov/pubmed/20445104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000779107
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